Antileishmanial Activities of ( Z )-2-(Nitroimidazolylmethylene)-3( 2H )-Benzofuranones: Synthesis, In Vitro Assessment, and Bioactivation by NTR 1 and 2
Copyright policy )Antileishmanial Activities of ( Z )-2-(Nitroimidazolylmethylene)-3( 2H )-Benzofuranones: Synthesis, In Vitro Assessment, and Bioactivation by NTR 1 and 2
The antileishmanial activity of a series of ( Z )-2-(heteroarylmethylene)-3(2 H )-benzofuranone derivatives, possessing 5-nitroimidazole or 4-nitroimidazole moieties, was investigated against Leishmania major promastigotes and some analogues exhibited prominent activities. Compounds with IC 50 values lower than 20 μM were further examined against L. donovani axenic amastigotes.
- University of Karachi Pakistan
- Wellcome Centre for Anti-Infectives Research United Kingdom
- University of Dundee United Kingdom
- International Center for Chemical and Biological Sciences Pakistan
- Tehran University of Medical Sciences Iran (Islamic Republic of)
/dk/atira/pure/subjectarea/asjc/3000/3004, Macrophages, Antiprotozoal Agents, 610, ntr1, Nitroreductases, name=Pharmacology, 540, name=Infectious Diseases, 2-(nitroimidazolylmethylene)-3(2H)-benzofuranone, name=Pharmacology (medical), Mice, Nitroimidazoles, /dk/atira/pure/subjectarea/asjc/2700/2736, /dk/atira/pure/subjectarea/asjc/2700/2725, Humans, Animals, NTR2, Leishmania major, Leishmania donovani
/dk/atira/pure/subjectarea/asjc/3000/3004, Macrophages, Antiprotozoal Agents, 610, ntr1, Nitroreductases, name=Pharmacology, 540, name=Infectious Diseases, 2-(nitroimidazolylmethylene)-3(2H)-benzofuranone, name=Pharmacology (medical), Mice, Nitroimidazoles, /dk/atira/pure/subjectarea/asjc/2700/2736, /dk/atira/pure/subjectarea/asjc/2700/2725, Humans, Animals, NTR2, Leishmania major, Leishmania donovani
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