Integrating reconfigurable computing with high-performance computing, exploiting reconfigurable hardware with their advantages to make up for the inadequacy of the existing high-performance computers had gradually become the high-performance computing solutions and trends. Based on comprehensively investigating the reconfigurable technologies, the paper presented a high-performance computing scheme in which the general-purpose processing nodes are connected to the dynamic partial reconfigurable computing nodes through the high-speed network. Using module-based partial reconfiguration design method, a FPGA based dynamic and partial reconfigurable computing node is designed. This node has the ability to do dynamic and partial reconfiguration and can load different computing units according to the different requirements. Dynamic partial reconfigurable computing node integrated microprocessor, memory, network interface, reconfigurable computing module, interface module are designed and implemented. The experimental results show that the system can achieve more functions with fewer resources; and the reconfigurable computing node can nicely complete the task and the system performance is effectively improved.