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Nuclear export of mRNA: from the site of transcription to the cytoplasm

descriptionPublicationkeyboard_double_arrow_right Article 15 May 2004 English Publisher:Elsevier BVJournal:Experimental Cell Research, volume 296, pages 12-20 (issn: 0014-4827,

Authors: Ulrike Kutay; Judith A. Erkmann;

doi: 10.1016/j.yexcr.2004.03.015

pmid: 15120988

Nuclear export of mRNA: from the site of transcription to the cytoplasm

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Abstract

Cellular mRNAs are produced in the nucleus and must be exported to the cytoplasm to allow for their translation into proteins. Recruitment of export factors to nascent mRNA starts cotranscriptionally and involves elaborate systems of quality control. Correctly processed mRNAs are committed for export in the form of large ribonucleoprotein complexes (mRNPs). Translocation of mRNPs through the nuclear pore complex (NPC) is mediated by a conserved heterodimeric transport receptor (NXF1/p15 in metazoa and Mex67p/Mtr2p in yeast) that bridges the interaction between the mRNP and the NPC. In this review, we describe the cis- and trans-requirements for mRNA export as well as the different mechanisms of recruiting export factors to mRNPs. We also discuss the significance of linking mRNA export with both downstream and upstream events in gene expression.

Related Organizations

University of North Carolina at Chapel Hill
United States
École Polytechnique Fédérale de Lausanne EPFL
Switzerland

Keywords

Cell Nucleus, Cytoplasm, Nucleocytoplasmic Transport Proteins, Ribonucleoproteins, Transcription, Genetic, Yeasts, Active Transport, Cell Nucleus, Animals, Humans, RNA, Messenger

20 Research products, page 1 of 2

THO complex subunit MFT1
2017IsRelatedTo
Single-strand telomeric DNA-binding protein GBP2
2017IsRelatedTo
Nucleolar protein 3
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Nucleoporin NUP116/NSP116
2017IsRelatedTo
THO complex subunit 2
2017IsRelatedTo
Nucleoporin NUP42
2017IsRelatedTo
Nucleoporin NUP159
2017IsRelatedTo
mRNA export factor MEX67
2017IsRelatedTo
Protein TEX1
2017IsRelatedTo
Nucleoporin GLE1
2017IsRelatedTo

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	110
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