Function of CBFβ/Bro proteins
Copyright policy )Function of CBFβ/Bro proteins
Mammalian core binding factor beta (CBFbeta) and Drosophila Brother (Bro) and Big-brother (Bgb) proteins are transcription factors that dimerize with mammalian Runx and Drosophila Runt and Lozenge proteins and augment their DNA binding affinity and transcriptional potency. CBFbeta is essential for development and sustenance of definitive hematopoiesis during mouse embryogenesis. Bro and Bgb are required for Runt/Lozenge functions in Drosophila development. CBFbeta contributes to leukemogenesis since the CBFB gene is specifically and consistently mutated by a chromosome 16 inversion found in patients with acute myeloid leukemia subtype M4Eo. The ubiquitous expression pattern of the CBFB gene suggests that it may play important roles in many other organ systems.
- National Human Genome Research Institute United States
- National Institute of Health Pakistan
Leukemia, Molecular Sequence Data, Core Binding Factor beta Subunit, Translocation, Genetic, DNA-Binding Proteins, Embryonic and Fetal Development, Transcription Factor AP-2, Proto-Oncogene Proteins, Core Binding Factor Alpha 2 Subunit, Animals, Drosophila Proteins, Humans, Insect Proteins, Amino Acid Sequence, Sequence Alignment, Transcription Factors
Leukemia, Molecular Sequence Data, Core Binding Factor beta Subunit, Translocation, Genetic, DNA-Binding Proteins, Embryonic and Fetal Development, Transcription Factor AP-2, Proto-Oncogene Proteins, Core Binding Factor Alpha 2 Subunit, Animals, Drosophila Proteins, Humans, Insect Proteins, Amino Acid Sequence, Sequence Alignment, Transcription Factors
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).62 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!