Chromosomal Mapping of Five Mouse G Protein γ Subunits
Copyright policy )Chromosomal Mapping of Five Mouse G Protein γ Subunits
Heterotrimeric G proteins, composed of alpha, beta, and gamma subunits, transduce signals from transmembrane receptors to a wide range of intracellular effectors. The G protein gamma subunits, which play an indispensible role in this communication, constitute a large and diverse multigene family. Using an interspecific backcross panel, we have determined the mouse chromosomal locations of five gamma subunit genes: gamma2, gamma8, gamma10, gamma12, and gammaCone. Combined with previous mapping studies, these data indicate that, with the possible exception of gamma1 and gamma11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes.
- Washington University in St. Louis United States
- University of Mary United States
Mice, Models, Genetic, GTP-Binding Proteins, Molecular Sequence Data, Animals, Chromosome Mapping, Humans, Inbreeding, Polymorphism, Restriction Fragment Length
Mice, Models, Genetic, GTP-Binding Proteins, Molecular Sequence Data, Animals, Chromosome Mapping, Humans, Inbreeding, Polymorphism, Restriction Fragment Length
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