Expression of the Mouse Hepatitis Virus Receptor by Central Nervous System Microglia
Copyright policy )Expression of the Mouse Hepatitis Virus Receptor by Central Nervous System Microglia
ABSTRACT Detection of the mouse hepatitis virus receptor within the central nervous system (CNS) has been elusive. Receptor expression on microglia was reduced during acute infection and restored following immune-mediated virus control. Receptor down regulation was independent of neutrophils, NK cells, gamma interferon, or perforin. Infection of mice devoid of distinct inflammatory cells revealed CD4 + T cells as the major cell type influencing receptor expression by microglia. In addition to demonstrating receptor expression on CNS resident cells, these data suggest that transient receptor down regulation on microglia aids in establishing persistence in the CNS by assisting virus infection of other glial cell types.
- University of California System United States
- University of Colorado Health United States
- University of Colorado Cancer Center United States
- University of New Mexico Hospital United States
CD4-Positive T-Lymphocytes, Mice, Inbred BALB C, Murine hepatitis virus, Down-Regulation, Mice, SCID, Carcinoembryonic Antigen, Mice, Inbred C57BL, Mice, Animals, Receptors, Virus, Microglia, Coronavirus Infections
CD4-Positive T-Lymphocytes, Mice, Inbred BALB C, Murine hepatitis virus, Down-Regulation, Mice, SCID, Carcinoembryonic Antigen, Mice, Inbred C57BL, Mice, Animals, Receptors, Virus, Microglia, Coronavirus Infections
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