Synthesis of the C1−C13 Fragment of Leucascandrolide A

descriptionPublicationkeyboard_double_arrow_right Article 03 Feb 2000 English Publisher:American Chemical Society (ACS)Journal:Organic Letters, volume 2, pages 597-599 (issn: 1523-7060, eissn: 1523-7052,

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Authors: M T, Crimmins; C A, Carroll; B W, King;

doi: 10.1021/ol991345t

pmid: 10814387

Synthesis of the C1−C13 Fragment of Leucascandrolide A

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Abstract

[reaction: see text] The synthesis of the C1-C13 fragment 3 of leucascandrolide A has been completed utilizing a stereoselective and regioselective reductive cleavage of a highly functionalized spiroketal to incorporate the cis-2,6-disubstituted tetrahydropyan. The spiroketal was constructed by addition of a lithiated pyrone 5 to aldehyde 6.

Related Organizations

University of North Carolina at Chapel Hill
United States

Keywords

Thermodynamics, Stereoisomerism, Sesquiterpenes

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ChemInform Abstract: Synthesis of the C1—C13 Fragment of Leucascandrolide A.
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