Sequences of the botulinal neurotoxin E derived from Clostridium botulinum type E (strain beluga) and Clostridium butyricum (strains ATCC 43181 and ATCC 43755)
Copyright policy )Sequences of the botulinal neurotoxin E derived from Clostridium botulinum type E (strain beluga) and Clostridium butyricum (strains ATCC 43181 and ATCC 43755)
Recently, it has been shown that two Clostridium butyricum strains (ATCC 43181 and ATCC 43755), isolated from cases of infant botulism, produce a botulinal neurotoxin type E (BoNT/E). Here we have determined the nucleotide sequences of the BoNT/E genes of these two C. butyricum strains and from C. botulinum E strain Beluga. We show that the sequences of the BoNT/E genes from the two C. butyricum strains are identical and differ in only 64 positions resulting in 39 amino acid changes (97% identity at the amino acid level) from that derived from C. botulinum. Our data suggest a transfer of the BoNT/E gene from C. botulinum to the originally nontoxigenic C. butyricum strains.
- Institut Pasteur France
Clostridium, Botulinum Toxins, Sequence Homology, Nucleic Acid, Molecular Sequence Data, Clostridium botulinum, Genetic Variation, Amino Acid Sequence, Polymerase Chain Reaction
Clostridium, Botulinum Toxins, Sequence Homology, Nucleic Acid, Molecular Sequence Data, Clostridium botulinum, Genetic Variation, Amino Acid Sequence, Polymerase Chain Reaction
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).98 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!