Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae.
Copyright policy )Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae.
The transcription of the Drosophila melanogaster 68C salivary gland glue gene Sgs-3 involves the interaction of a distal and a proximal regulatory region. These are marked in vivo by a specific chromatin structure which is established sequentially during development, starting early in embryogenesis. The distal region is characterized by a stage- and tissue-specific DNase I hypersensitive site. A stage- and tissue-specific factor, GEBF-I, binds in this region and is missing in 2B5 mutant larvae which lack Sgs-3 transcripts. This binding involves the simultaneous interaction with two distinct DNA sequences which induces conformational changes in the protein. Salivary glands acquire competence to respond to ecdysone in the mid-third larval instar, whereafter the hormone rapidly induces both the GEBF-I protein and Sgs-3 transcription.
Ecdysone, Base Sequence, Transcription, Genetic, Glue Proteins, Drosophila, Molecular Sequence Data, Restriction Mapping, Age Factors, Oligonucleotides, Chromosome Mapping, Regulatory Sequences, Nucleic Acid, Chromatin, DNA-Binding Proteins, Drosophila melanogaster, Enhancer Elements, Genetic, Gene Expression Regulation, Genes, Animals, Protein Binding, Transcription Factors
Ecdysone, Base Sequence, Transcription, Genetic, Glue Proteins, Drosophila, Molecular Sequence Data, Restriction Mapping, Age Factors, Oligonucleotides, Chromosome Mapping, Regulatory Sequences, Nucleic Acid, Chromatin, DNA-Binding Proteins, Drosophila melanogaster, Enhancer Elements, Genetic, Gene Expression Regulation, Genes, Animals, Protein Binding, Transcription Factors
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