Effect of 1‐ and 2‐Month High‐Dose Alpha‐Linolenic Acid Treatment on 13C‐Labeled Alpha‐Linolenic Acid Incorporation and Conversion in Healthy Subjects
Copyright policy )Effect of 1‐ and 2‐Month High‐Dose Alpha‐Linolenic Acid Treatment on 13C‐Labeled Alpha‐Linolenic Acid Incorporation and Conversion in Healthy Subjects
ScopeThe study aims at identifying 1) the most sensitive compartment among plasma phospholipids, erythrocytes, and LDL for studying alpha‐linolenic acid (ALA) conversion, and 2) whether ALA incorporation and conversion is saturable after administration of 13C‐labeled ALA‐rich linseed oil (LO). The effect of a daily intake of 7 g nonlabeled LO (>43% w/w ALA) for 1 month after bolus administration of 7 g 13C‐labeled LO on day 1, and for 2 months after bolus administration of 7 g 13C‐labeled LO on day 1 and day 29 on 13C‐ALA incorporation and conversion into its higher homologs is investigated in healthy volunteers.Methods and resultsIncorporation and conversion of LO‐derived 13C‐labeled ALA is quantified by applying compartmental modeling. After bolus administration, a fractional conversion of approximately 30% from 13C‐ALA to 13C‐DHA is calculated as reflected by the LDL compartment. Treatment with LO for 8 weeks induces a mean reduction of 13C‐ALA conversion to 13C‐DHA by 48% as reflected by the LDL compartment, and a mean reduction of the 13C‐ALA incorporation into LDL by 46%.ConclusionA 2‐month dietary intake of a high dose of LO is sufficient to reach saturation of ALA incorporation into LDL particles, which are responsible for ALA distribution in the body.
Adult, Male, EICOSAPENTAENOIC ACID, Erythrocytes, Linseed Oil, 104009 Lebensmittelchemie, Docosahexaenoic Acids, COMPARTMENTAL ANALYSES, LINSEED OIL, omega‐3 fatty acids, ALA conversion, METABOLISM, Models, Biological, LDL, 104009 Food chemistry, Fatty Acids, Omega-3, 303009 Ernährungswissenschaften, Humans, Research Articles, Phospholipids, POLYUNSATURATED FATTY-ACIDS, Carbon Isotopes, omega-3 fatty acids, PLASMA, Body Weight, alpha-Linolenic Acid, HUMANS, linseed oil, DOCOSAHEXAENOIC ACID, compartment model, Healthy Volunteers, N-3, ADIPOSE-TISSUE, Eicosapentaenoic Acid, Lipoproteins, IDL, 303009 Nutritional sciences
Adult, Male, EICOSAPENTAENOIC ACID, Erythrocytes, Linseed Oil, 104009 Lebensmittelchemie, Docosahexaenoic Acids, COMPARTMENTAL ANALYSES, LINSEED OIL, omega‐3 fatty acids, ALA conversion, METABOLISM, Models, Biological, LDL, 104009 Food chemistry, Fatty Acids, Omega-3, 303009 Ernährungswissenschaften, Humans, Research Articles, Phospholipids, POLYUNSATURATED FATTY-ACIDS, Carbon Isotopes, omega-3 fatty acids, PLASMA, Body Weight, alpha-Linolenic Acid, HUMANS, linseed oil, DOCOSAHEXAENOIC ACID, compartment model, Healthy Volunteers, N-3, ADIPOSE-TISSUE, Eicosapentaenoic Acid, Lipoproteins, IDL, 303009 Nutritional sciences
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