Parvin-β Inhibits Breast Cancer Tumorigenicity and Promotes CDK9-Mediated Peroxisome Proliferator-Activated Receptor Gamma 1 Phosphorylation
Copyright policy )Parvin-β Inhibits Breast Cancer Tumorigenicity and Promotes CDK9-Mediated Peroxisome Proliferator-Activated Receptor Gamma 1 Phosphorylation
Parvin-beta is a focal adhesion protein downregulated in human breast cancer cells. Loss of Parvin-beta contributes to increased integrin-linked kinase activity, cell-matrix adhesion, and invasion through the extracellular matrix in vitro. The effect of ectopic Parvin-beta expression on the transcriptional profile of MDA-MB-231 breast cancer cells, which normally do not express Parvin-beta, was evaluated. Particular emphasis was placed upon propagating MDA-MB-231 breast cancer cells in three-dimensional culture matrices. Interestingly, Parvin-beta reexpression in MDA-MB-231 cells increased the mRNA expression, serine 82 phosphorylation (mediated by CDK9), and activity of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma), and there was a concomitant increase in lipogenic gene expression as a downstream effector of PPARgamma. Importantly, Parvin-beta suppressed breast cancer growth in vivo, with associated decreased proliferation. These data suggest that Parvin-beta might influence breast cancer progression.
- University of Pennsylvania United States
- University of Toronto Canada
- Abramson Cancer Center United States
- Hospital for Sick Children Canada
Transcription, Genetic, Gene Expression Profiling, Breast Neoplasms, Cell Differentiation, Lipid Metabolism, Cyclin-Dependent Kinase 9, Gene Expression Regulation, Neoplastic, PPAR gamma, Mice, Phosphoserine, Cell Transformation, Neoplastic, Cell Line, Tumor, Animals, Humans, Actinin, RNA, Messenger, Phosphorylation, Neoplasm Transplantation, Cell Proliferation
Transcription, Genetic, Gene Expression Profiling, Breast Neoplasms, Cell Differentiation, Lipid Metabolism, Cyclin-Dependent Kinase 9, Gene Expression Regulation, Neoplastic, PPAR gamma, Mice, Phosphoserine, Cell Transformation, Neoplastic, Cell Line, Tumor, Animals, Humans, Actinin, RNA, Messenger, Phosphorylation, Neoplasm Transplantation, Cell Proliferation
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