Synthesis and Characterization of Novel Biodegradable Copolymers of 5‐Benzyloxy‐1,3‐dioxan‐2‐one and Glycolide

descriptionPublicationkeyboard_double_arrow_right Article 28 Nov 2003 English Publisher:WileyJournal:Macromolecular Rapid Communications, volume 24, pages 1,066-1,069 (issn: 1022-1336, eissn: 1521-3927,

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Authors: Si‐Xue Cheng; Zhi‐Mei Miao; Lian‐Sheng Wang; Ren‐Xi Zhuo;

doi: 10.1002/marc.200300085

Synthesis and Characterization of Novel Biodegradable Copolymers of 5‐Benzyloxy‐1,3‐dioxan‐2‐one and Glycolide

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Abstract

AbstractA series of novel biodegradable random copolymers of 5‐benzyloxy‐1,3‐dioxan‐2‐one (5‐benzyloxy‐trimethylene carbonate, BTMC) and glycolide were synthesized by ring‐opening polymerization. The copolymers were characterized by nuclear magnetic resonance (NMR) spectroscopy and gel permeation chromatography (GPC). The incorporation of BTMC units into the copolymer chains results in good solubility of the polymers in common solvents. The in vitro degradation rate can be tailored by adjusting the composition of the copolymers.The in vitro degradation of the homopolymers and poly(BTMC‐co‐GA) copolymers.magnified imageThe in vitro degradation of the homopolymers and poly(BTMC‐co‐GA) copolymers.

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Wuhan University
China (People's Republic of)

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