Systemic lupus erythematosus is a common autoimmune disorder that frequently is complicated by additional autoimmune diseases. There is a correspondence between hepatic diseases and systemic lupus erythematosus that ranges from subclinical elevations of liver enzymes to hepatic infarction. We present a rare case of portal hypertensive duodenopathy in a patient with autoimmune hepatitis/liver cirrhosis associated with systemic lupus erythematosus. Patients with systemic lupus erythematosus who present with upper gastrointestinal bleed should be evaluated for abnormal liver functions and have portal hypertensive duodenopathy included in the differential diagnosis.