Association between HLA Class II Locus and the Susceptibility to Artemisia Pollen–Induced Allergic Rhinitis in Chinese Population
Copyright policy )Association between HLA Class II Locus and the Susceptibility to Artemisia Pollen–Induced Allergic Rhinitis in Chinese Population
OBJECTIVEThe aim of the study was to determine whether susceptibility or resistance to Artemisia pollen‐induced allergic rhinitis was associated with HLA class II DQA1, DQB1 loci.STUDY DESIGN AND SETTINGForty‐one subjects with allergic rhinitis and 41 healthy controls from Beijing were genotyped at HLA class II DQA1, DQB1 alleles by polymerase chain reaction amplification with sequence‐specific primers‐based technique.RESULTSThe allele frequencies of HLA‐DQA1*0201, DQB1*0602 were lower in patients with allergic rhinitis compared with the controls (24.39% versus 46.34%, P = 0.038; 4.88% versus 26.83%, P = 0.007), and the frequency of DQA1*0302 was higher among patients than the controls (58.54% versus 14.63%, P = 0.00004, Pc = 0.0004).CONCLUSION AND SIGNIFICANCE: HLA‐DQA1 and DQB1 genes may be involved in the development of Artemisia pollen‐induced allergic rhinitis. HLA‐DQA1*0201, DQB1*0602 alleles may be a protective factor and DQA1*0302 may be a susceptible factor for Artemisia pollen‐induced allergic rhinitis.
- Peking University China (People's Republic of)
- Peking University People's Hospital China (People's Republic of)
- Peking University China (People's Republic of)
Adult, Male, China, Rhinitis, Allergic, Seasonal, Middle Aged, HLA-DQ alpha-Chains, Artemisia, Asian People, Seroepidemiologic Studies, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Pollen, Female, Genetic Predisposition to Disease
Adult, Male, China, Rhinitis, Allergic, Seasonal, Middle Aged, HLA-DQ alpha-Chains, Artemisia, Asian People, Seroepidemiologic Studies, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Pollen, Female, Genetic Predisposition to Disease
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