Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways
Copyright policy )Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways
AbstractHere we define the expression of ≈100 transcription factors in progenitors and neurons of the developing basal ganglia. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most GABAergic projection neurons of the basal ganglia. This analysis identified Dlx‐dependent and Dlx‐independent pathways. The Dlx‐independent pathway depends in part on the function of the Mash1 b‐HLH transcription factor. These analyses define core transcriptional components that differentially specify the identity and differentiation of the striatum, nucleus accumbens, and septum. J. Comp. Neurol. 512:556–572, 2009. © 2008 Wiley‐Liss, Inc.
- University of California System United States
- University of California, San Francisco United States
Cerebral Cortex, Homeodomain Proteins, Mice, Knockout, Neurons, Stem Cells, Gene Expression Regulation, Developmental, Cell Differentiation, Epistasis, Genetic, Basal Ganglia, Corpus Striatum, Mice, Neural Pathways, Basic Helix-Loop-Helix Transcription Factors, Morphogenesis, Animals, Transcription Factors
Cerebral Cortex, Homeodomain Proteins, Mice, Knockout, Neurons, Stem Cells, Gene Expression Regulation, Developmental, Cell Differentiation, Epistasis, Genetic, Basal Ganglia, Corpus Striatum, Mice, Neural Pathways, Basic Helix-Loop-Helix Transcription Factors, Morphogenesis, Animals, Transcription Factors
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