Citizen Science (CS) can help change the paradigm of science communication. To test this, 38 ongoing CS projects from Italy, Portugal and Spain have been selected by the H2020 NEWSERA project to act as pilots in the development of communication strategies, specifically targeting stakeholders in the quadruple helix. The projects, together with stakeholder representatives and science communication and journalism professionals participated in a series of workshops — #CitSciComm Labs — where communication strategies were co-designed, using adapted design-thinking methods. The innovative methodological approach is hereby presented and can be an inspiration for others willing to implement improved communication strategies to target different stakeholders.