According to the three-dimensional P-velocity model of the mantle under Eurasia obtained by the Taylor approximation method, the analysis of the velocity structure of the mantle (to depths of 2500 km south of 50° N and 1700 km north) in the territory of the Dnieper-Donetsk depression was carried out in order to determine the possible areas of primary hydrogen release. Primary hydrogen is formed in the core and lower mantle, can be transferred to the surface (according to I.L. Gufeld). According to seismotomography, nine superdeep mantle fluids are isolated on the territory of Ukraine, the routes of which are defined as subvertical columns of alternation of high-speed and low-speed anomalies. In addition to the presence of superdeep mantle fluids in the study area, the following characteristics were analyzed: the depth of the main geodynamic boundary, the influence of the high-velocity transition zone of the upper mantle (propagating northward into the low-velocity transition zone of the upper mantle of the East European platform), the depth of the Moho boundary, gravity mantle anomalies and heat flow. The totality of the studies performed allowed us to conclude that, according to seismic tomography data, the Izyumsky and the eastern part of the Lokhvitsky segment of the Dnieper-Donetsk depression are promising areas for detecting primary hydrogen in the territory of the Dnieper-Donetsk depression.