KIR2DS4 allelic variants: Differential effects on in utero and intrapartum HIV-1 mother-to-child transmission
Copyright policy )KIR2DS4 allelic variants: Differential effects on in utero and intrapartum HIV-1 mother-to-child transmission
KIR2DS4 is the only activating gene within the A haplotype, and alleles of KIR2DS4 can encode either functional (KIR2DS4-f) or non-functional (KIR2DS4-v) variants. To establish the role of KIR2DS4 in the context of HIV-1 mother-to-child transmission, we KIR genotyped 145 HIV-1 non-transmitting mothers (NT) and their exposed uninfected infants (EU), and 72 HIV-1 transmitting mothers (TR) and their infected infants [intrapartum (IP), in utero (IU) or IU2 (an IU-enriched infected group)]. The frequency of KIR2DS4-v was significantly higher in IU2 infants compared to EU infants (P=0.022, OR=2.88); this association was more significant amongst AA haplotypes (P=0.004, OR=18.4). Possession of KIR2DS4-f in the mother with absence in the infant (M+I- discordance) was associated with a higher risk of IP transmission (P=0.005, OR=3.84); whilst in M-I+ discordance, infant possession of KIR2DS4-v was associated with increased risk of IU acquisition (P=0.002; OR=6.40). This study highlights the importance of KIR2DS4 in HIV-1 transmission/acquisition.
- Columbia University United States
- King’s University United States
- National Institute for Communicable Diseases South Africa
- University of the Witwatersrand South Africa
- Perinatal HIV Research Unit South Africa
Adult, Male, Risk, Infant, HIV Infections, Viral Load, Infectious Disease Transmission, Vertical, Gene Frequency, Haplotypes, Receptors, KIR, HIV-1, Humans, Protein Isoforms, Female, Alleles
Adult, Male, Risk, Infant, HIV Infections, Viral Load, Infectious Disease Transmission, Vertical, Gene Frequency, Haplotypes, Receptors, KIR, HIV-1, Humans, Protein Isoforms, Female, Alleles
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