Molecular defects in coagulation Factor VIII and their impact on Factor VIII function
Copyright policy )Molecular defects in coagulation Factor VIII and their impact on Factor VIII function
Molecular defects in Factor VIII (FVIII), such as haemophilia A‐related mutations or denaturative conformational changes, may affect the stability of FVIII as well as its interactions with physiological activators, von Willebrand Factor, phospholipid, or conformationally sensitive antibodies. We summarize the contemporary assays which allow identification of impaired functional interactions of FVIII that cause a reduction or loss of its cofactor activity and/or increased immunogenicity. These assays can potentially be used for detection of molecular defects in FVIII and elucidation of the function impaired by these defects.
- University of Michigan–Flint United States
- George Washington University United States
- Nara Medical University Japan
- American Red Cross United States
- University of Lübeck Germany
Conformational changes, Conformational changes ; Factor VIII ; Haemophilia A ; Mutations ; Phospholipid binding ; Surface plasmon resonance, Factor VIII, Protein Conformation, Surface Plasmon Resonance, Hemophilia A, Phospholipid Binding, Oncology and Hematology, Phospholipid binding, Surface plasmon resonance, Health Sciences, Haemophilia A, Mutation, Conformational Changes, Humans, Blood Coagulation, Mutations
Conformational changes, Conformational changes ; Factor VIII ; Haemophilia A ; Mutations ; Phospholipid binding ; Surface plasmon resonance, Factor VIII, Protein Conformation, Surface Plasmon Resonance, Hemophilia A, Phospholipid Binding, Oncology and Hematology, Phospholipid binding, Surface plasmon resonance, Health Sciences, Haemophilia A, Mutation, Conformational Changes, Humans, Blood Coagulation, Mutations
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