Although contributing greatly to current criminological theory and research on crime and desistance, Sampson and Laub's theory of age-graded informal social control is limited in explaining gender differences in desistance. The authors addressed this limitation by comparing how adult institutions such as marriage, family, and employment affect illicit drug use for women compared with men. The authors analyzed logistic panel models with fixed effects using National Youth Survey data and found gender differences in the predictors of changes in illicit substance use. Although marriage reduced the odds of drug use for men, it was the importance or strength of a relationship that altered illicit drug use for women. The authors also found other gender differences regarding children and the emphasis placed on employment and family by respondents. This research adds to the existing literature on desistance and furthers knowledge about the gendered nature of Sampson and Laub's theory.