The role of glucocorticoid in SIRPα and SHP-1 gene expression in AIHA patients
Copyright policy )The role of glucocorticoid in SIRPα and SHP-1 gene expression in AIHA patients
The aim of this work was to evaluate the regulation of SIRP alpha, an inhibitory phagocyte receptor, and the phosphatase SHP-1 in monocytes of patients with autoimmune hemolytic anemia, and the role of dexamethasone on SIRP alpha and SHP-1 gene expression and erythrophagocytosis in vitro. SIRP alpha and SHP-1 expression was higher in monocytes from AIHA patients compared with normal, returning to normal after glucocorticoid therapy. SIRP alpha and SHP-1 mRNA expression was upregulated in healthy monocytes treated with dexamethasone compared with basal; however, the erythrophagocytic ability was not altered. Our results point to a minor role of SIRP alpha and SHP-1 in determining AIHA.
- UNIVERSIDADE DE SAO PAULO Brazil
- State University of Campinas Brazil
- Universidade de São Paulo Brazil
Protein Tyrosine Phosphatase, Non-Receptor Type 6, Antigens, Differentiation, Dexamethasone, Gene Expression Regulation, Phagocytosis, Leukocytes, Mononuclear, Humans, Anemia, Hemolytic, Autoimmune, Receptors, Immunologic, Glucocorticoids, Cells, Cultured
Protein Tyrosine Phosphatase, Non-Receptor Type 6, Antigens, Differentiation, Dexamethasone, Gene Expression Regulation, Phagocytosis, Leukocytes, Mononuclear, Humans, Anemia, Hemolytic, Autoimmune, Receptors, Immunologic, Glucocorticoids, Cells, Cultured
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