Objective: Non-pharmacological intervention to manage the health by healthybalanced diet and life style modifications. Study Design: Randomized Cross sectional Study.Place & Duration: Pakistan Council of Scientific and Industrial Research (PCSIR) laboratoryKarachi from March 2012 to June 2013. Material & Methods: In this study, 210 volunteers wereincluded (137 male and 73 female) aged between 25-60 years. The study was conducted withthe questionnaire being filled at PCSIR labs, Karachi. The study period included from March toMay 2012. One year later the same group of volunteers were re-examined from March to June2013, who managed to alter the diet and life style for one year. The questionnaire was filled by anexpert well versed in collecting the data from the patients who attended the OPD at PCSIR labs.Results: The results indicate that a lot of people in our population lead a sedentary life styleand do not take part in physical activity which leads to health problems due to comparativelyless energy / calories expenditure. Conclusion: Efforts should be made globally to createa public awareness and provide healthy environment to the people about pursuing healthylifestyles. Several life style behaviors may influence to maintain energy balance over long term.The primary approach for achieving weight loss is lifestyle changes which includes reducedintake of calories and increase in physical activity. Regular, moderate intensity physical activityenhances long term weight maintenance and balance between energy input and output.