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Neuroscience Letters
Article . 1991 . Peer-reviewed
License: Elsevier TDM
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Neuroscience Letters
Article . 1991
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Neuroscience Letters
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Regional GABA-stimulated chloride uptake in amygdala kindled rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1991 English Publisher:Elsevier BVJournal:Neuroscience Letters, volume 123, pages 269-272 (issn: 0304-3940, Copyright policy )
Authors: Ted H. Chiu; Elizabeth I. Tietz;

doi: 10.1016/0304-3940(91)90948-s

pmid: 2027542

Regional GABA-stimulated chloride uptake in amygdala kindled rats

Abstract

gamma-Aminobutyric acid (GABA)-stimulated 36chloride (Cl-) influx into membrane vesicles derived from cerebral cortex, hippocampus, cerebellum and midbrain/brainstem was evaluated in naive rats and amygdala or sham kindled rats. GABA-stimulated 36Cl- uptake was greatest in cortex and hippocampus of naive rats. One week after amygdala kindling, 10 microM GABA-stimulated 36Cl- influx was significantly reduced in each brain region, except midbrain/brainstem, indicating a regional variation in impaired GABAergic function. Midazolam potentiation of GABA-mediated Cl- flux showed a regional variation. The effect of midazolam in kindled rats indicated either an increase in efficiency of GABA/benzodiazepine coupling in areas of reduced GABA function or its ability to restore Cl- channel function to the pre-kindled state.

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Keywords

Male, Radioisotopes, Midazolam, Brain, Drug Synergism, Rats, Inbred Strains, Amygdala, Rats, Chlorides, Kindling, Neurologic, Animals, Tissue Distribution, Chlorine, gamma-Aminobutyric Acid

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
18
Average
Average
Top 10%
Related to Research communities
Neuroscience
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