Structural and Functional Organization of the ESCRT-I Trafficking Complex
Copyright policy )Structural and Functional Organization of the ESCRT-I Trafficking Complex
The endosomal sorting complex required for transport (ESCRT) complexes are central to receptor downregulation, lysosome biogenesis, and budding of HIV. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37. The crystal structures of a Vps23:Vps28 core subcomplex and the Vps23:Vps28:Vps37 core were solved at 2.1 and 2.8 A resolution. Each subunit contains a structurally similar pair of helices that form the core. The N-terminal domain of Vps28 has a hydrophobic binding site on its surface that is conformationally dynamic. The C-terminal domain of Vps28 binds the ESCRT-II complex. The structure shows how ESCRT-I is assembled by a compact core from which the Vps23 UEV domain, the Vps28 C domain, and other domains project to bind their partners.
- National Institute of Health Pakistan
- University of California, San Diego United States
- University of California, San Diego United States
- Howard Hughes Medical Institute United States
- National Institute of Diabetes and Digestive and Kidney Diseases United States
Models, Molecular, Saccharomyces cerevisiae Proteins, Endosomal Sorting Complexes Required for Transport, Biochemistry, Genetics and Molecular Biology(all), Protein Conformation, Recombinant Fusion Proteins, Amino Acid Motifs, Molecular Sequence Data, Vesicular Transport Proteins, Saccharomyces cerevisiae, Protein Transport, Phenotype, Protein Interaction Mapping, Amino Acid Sequence, Sequence Alignment
Models, Molecular, Saccharomyces cerevisiae Proteins, Endosomal Sorting Complexes Required for Transport, Biochemistry, Genetics and Molecular Biology(all), Protein Conformation, Recombinant Fusion Proteins, Amino Acid Motifs, Molecular Sequence Data, Vesicular Transport Proteins, Saccharomyces cerevisiae, Protein Transport, Phenotype, Protein Interaction Mapping, Amino Acid Sequence, Sequence Alignment
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