Ftm is a novel basal body protein of cilia involved in Shh signalling
Copyright policy )Ftm is a novel basal body protein of cilia involved in Shh signalling
In this study we show in mice that Ftm (Rpgrip1l) is located at the ciliary basal body. Our data reveal that Ftm is necessary for developmental processes such as the establishment of left-right asymmetry and patterning of the neural tube and the limbs. The loss of Ftm affects the ratio of Gli3 activator to Gli3 repressor, suggesting an involvement of Ftm in Shh signalling. As Ftm is not essential for cilia assembly but for full Shh response, Ftm can be considered as a novel component for cilium-related Hh signalling. Furthermore,the absence of Ftm in arthropods underlines the divergence between vertebrate and Drosophila Hh pathways.
- Heinrich Heine University Düsseldorf Germany
- University of Duesseldorf Germany
- Cornell University United States
Mice, Knockout, Kruppel-Like Transcription Factors, Extremities, Nerve Tissue Proteins, Embryo, Mammalian, Mice, Polydactyly, Phenotype, Zinc Finger Protein Gli3, Mutation, Animals, Hedgehog Proteins, Cilia, Neural Tube Defects, Cells, Cultured, Adaptor Proteins, Signal Transducing, Body Patterning, Signal Transduction
Mice, Knockout, Kruppel-Like Transcription Factors, Extremities, Nerve Tissue Proteins, Embryo, Mammalian, Mice, Polydactyly, Phenotype, Zinc Finger Protein Gli3, Mutation, Animals, Hedgehog Proteins, Cilia, Neural Tube Defects, Cells, Cultured, Adaptor Proteins, Signal Transducing, Body Patterning, Signal Transduction
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