Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche
Copyright policy )Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche
Key PointsIn a mouse model, BCR-ABL1+ leukemia stem cells are more dependent on selectins and their ligands for homing and engraftment than normal HSCs. Blockade of selectin-ligand interactions might prevent leukemic engraftment and relapse in autografted patients.
- Harvard University United States
- Massachusetts General Hospital United States
- Institute of Oncology Research Switzerland
- Tufts Medical Center United States
- University of California System United States
Cells, Knockout, Fusion Proteins, bcr-abl, Bone Marrow Cells, BCR-ABL Positive: genetics, Inbred C57BL, Ligands, Neoplastic Stem Cells: metabolism, Mice, Bone Marrow, Cell Movement, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Animals, Humans, Neoplasm Invasiveness, Chronic, Stem Cell Niche, Bone Marrow: pathology, Inbred BALB C, Cells, Cultured, Mice, Knockout, Mice, Inbred BALB C, Cultured, Leukemia, Cell Movement: genetics, Fusion Proteins, bcr-abl: genetics, Selectins: physiology, Mice, Inbred C57BL, HEK293 Cells, Bone Marrow Cells: pathology, physiology, Neoplastic Stem Cells, Selectins, pathology, metabolism, Myelogenous
Cells, Knockout, Fusion Proteins, bcr-abl, Bone Marrow Cells, BCR-ABL Positive: genetics, Inbred C57BL, Ligands, Neoplastic Stem Cells: metabolism, Mice, Bone Marrow, Cell Movement, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Animals, Humans, Neoplasm Invasiveness, Chronic, Stem Cell Niche, Bone Marrow: pathology, Inbred BALB C, Cells, Cultured, Mice, Knockout, Mice, Inbred BALB C, Cultured, Leukemia, Cell Movement: genetics, Fusion Proteins, bcr-abl: genetics, Selectins: physiology, Mice, Inbred C57BL, HEK293 Cells, Bone Marrow Cells: pathology, physiology, Neoplastic Stem Cells, Selectins, pathology, metabolism, Myelogenous
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