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Studies Towards new Ribavirin Nucleoside Analogs

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Sep 2013Publisher:Editora Edgard BlücherJournal:Proceedings of the 14th Brazilian Meeting on Organic Synthesis Proceedings

Authors: Nadège Lubin-Germain; Jacques Uziel; Rodrigo Octavio Mendonça Alves de Souza; Leandro Soter de Mariz e Miranda;

doi: 10.5151/chempro-14bmos-r0137-1

Studies Towards new Ribavirin Nucleoside Analogs

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Abstract

Hepatitis C is a viral infection that commits about 3-4 million people per year worldwide. Its treatment consists mainly in the administration of interferon α and Ribavirin. However the collateral effects associated with this treatment, specifically attributed to the Ribavirin, precludes the treatment in some patients, which make the search for new drugs a very important issue. The discovery of a high active Ribavirin analog denominated SR91, figure 1, towards inhibition of IMP-DH prompted us to further investigate and pursuit in the direction of synthesizing new derivatives guided by a in silico docking study.

Related Organizations

Federal University of Rio de Janeiro
Brazil
CY Cergy Paris University
France
Rio de Janeiro Federal Institute of Education, Science and Technology
Brazil

2 Research products, page 1 of 1

Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture.
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