Casein kinase 1 delta (CK1δ) interacts with the SNARE associated protein snapin
Copyright policy )Casein kinase 1 delta (CK1δ) interacts with the SNARE associated protein snapin
In this study we identified snapin as an interaction partner of the CK1 isoform delta (CK1δ) in the yeast two‐hybrid system and localized the interacting domains of both proteins. The interaction of CK1δ with snapin was confirmed by co‐immunoprecipitation. Snapin was phosphorylated by CK1δ in vitro. Both proteins localized in close proximity in the perinuclear region, wherein snapin was found to associate with membranes of the Golgi apparatus. The identification of snapin as a new substrate of CK1δ points towards a possible function for CK1δ in modulating snapin specific functions.
- University of Bristol United Kingdom
- Stony Brook University United States
- University of Bristol (UoB) United Kingdom
- University of Ulm Germany
CK1δ, Soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor, Vesicular Transport Proteins, Golgi Apparatus, Vesicle transport, Snapin, Protein Structure, Tertiary, Mice, Casein Kinase Idelta, Two-Hybrid System Techniques, Animals, Humans, Phosphorylation, SNARE Proteins, Yeast two-hybrid system, Protein Processing, Post-Translational, Protein Binding
CK1δ, Soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor, Vesicular Transport Proteins, Golgi Apparatus, Vesicle transport, Snapin, Protein Structure, Tertiary, Mice, Casein Kinase Idelta, Two-Hybrid System Techniques, Animals, Humans, Phosphorylation, SNARE Proteins, Yeast two-hybrid system, Protein Processing, Post-Translational, Protein Binding
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