The role of the BAFF/APRIL system on T cell function
Copyright policy )The role of the BAFF/APRIL system on T cell function
BAFF is a key factor controlling B cell survival and maturation and its over-expression promotes B cell-mediated autoimmune disorders and participates in the progression of B cell lymphomas. Yet, BAFF and a related ligand APRIL are expressed by T lymphocytes and modulate their functions. BAFF and APRIL promote T cell activation and survival. BAFF over-expression in transgenic (Tg) mice enhances T helper 1 (Thl)-driven delayed-type hypersensitivity (DTH), but inhibits T helper 2 (Th2) cell-mediated allergic airway inflammation in mice. Some of these effects are also dependent on BAFF-induced modification of the B cell compartment. Therefore, direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation.
- Garvan Institute of Medical Research Australia
- St Vincent's Hospital Sydney Australia
Homeodomain Proteins, Inflammation, Mice, Knockout, Lymphokines, Transmembrane Activator and CAML Interactor Protein, Tumor Necrosis Factor Ligand Superfamily Member 13, Autoimmunity, Cell Differentiation, Mice, Transgenic, Lymphocyte Activation, Mice, T-Lymphocyte Subsets, B-Cell Activating Factor, Animals, Humans, B-Cell Maturation Antigen, B-Cell Activation Factor Receptor
Homeodomain Proteins, Inflammation, Mice, Knockout, Lymphokines, Transmembrane Activator and CAML Interactor Protein, Tumor Necrosis Factor Ligand Superfamily Member 13, Autoimmunity, Cell Differentiation, Mice, Transgenic, Lymphocyte Activation, Mice, T-Lymphocyte Subsets, B-Cell Activating Factor, Animals, Humans, B-Cell Maturation Antigen, B-Cell Activation Factor Receptor
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