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SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

Authors: David White; Toyin Ogunrinu-Babarinde; Louis B. Nabors; Susan Campbell; Stephanie M. Robert; Meredith A. Reid; Kenneth T. Holt; +7 Authors

SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

Abstract

SLC7A11, the catalytic subunit of the cystine/glutamate antiporter, System x c − (SXC), is up-regulated in a subpopulation of patient gliomas, where it is responsible for excitotoxic glutamate release, accelerated tumor growth, and tumor-associated seizures.

Keywords

Neurons, Amino Acid Transport System y+, Neurotoxins, Genomics, Glioma, Survival Analysis, Glutamates, Seizures, Edema, Humans

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    250
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
250
Top 1%
Top 10%
Top 1%
bronze