Serological HLA class I alleles in Senegalese blood donors detected HBs Ag positive
Copyright policy )Serological HLA class I alleles in Senegalese blood donors detected HBs Ag positive
We analysed the HLA class I alleles in 96 blood donors HBs Ag positive compared with 93 healthy control individuals (HBs negative). The most frequent HLA-A, -B, -C alleles found were, A23 (33.6%); A2 (25%); A30 (25%); B8 (31.5%); B7 (16.3%); B58 (11.9%); B35 (11.9%); B49 (11.9%); B53 (10.8%); Cw7 (39.1%); Cw3 (36.9%); Cw4 (36.9%). Significant differences (P<0.001) were found between the blood donors and the controls for the following HLA alleles, A1; A23; B8 and Cw3. The detection of HBe antigen was positive in 26/84 blood donors. It was observed a significant difference (P<0.01; odds ratios (OR)=6.25) between positive and negative HBe antigens blood donors for HLA-A1 allele.
- Cheikh Anta Diop University Senegal
- Institut Pasteur de Dakar Senegal
- Institut Pasteur France
Adult, Male, Hepatitis B Surface Antigens, Adolescent, Genotype, Genes, MHC Class I, Blood Donors, Hepatitis B, Senegal, HLA-B8 Antigen, Gene Frequency, Seroepidemiologic Studies, Carrier State, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Hepatitis B e Antigens, HLA-A1 Antigen
Adult, Male, Hepatitis B Surface Antigens, Adolescent, Genotype, Genes, MHC Class I, Blood Donors, Hepatitis B, Senegal, HLA-B8 Antigen, Gene Frequency, Seroepidemiologic Studies, Carrier State, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Hepatitis B e Antigens, HLA-A1 Antigen
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