Association of SNPs in CDKN2A (P14ARF) Tumour Suppressor Gene With Endometrial Cancer in Postmenopausal Women
Copyright policy )Association of SNPs in CDKN2A (P14ARF) Tumour Suppressor Gene With Endometrial Cancer in Postmenopausal Women
This research was aimed to evaluate the association between three selected single nucleotide polymorphisms (SNPs) within the CDKN2A (P14ARF) tumour suppressor gene and the incidence of endometrial cancer (EC) in postmenopausal women.The study included 194 postmenopausal women; 144 with EC and 50 non-cancer controls. Genotypes in P14ARF rs3088440, rs3731217 and rs3731245 polymorphisms were assayed using PCR-RFLP and confirmed by sequencing.Regarding the rs3088440 polymorphism, CT, and CT-TT genotypes, were more prevalent among EC patients than in controls (OR=5.55, p=0.023, OR=5.29, p=0.027; and OR=2.92, p=0.023, respectively). The T allele within rs3088440 was more prevalent in EC females than in controls (χ2=4.7, p=0.030). Considering rs3731217, TG and TG-GG genotypes were less prevalent among EC (OR=0.34, p=0.024 or p=0.023; and OR=0.38, p=0.035, respectively).Polymorphisms in the CDKN2A gene are associated with EC in postmenopausal women.
- Medical University of Lodz Poland
- UNIVERSYTET MEDYCZNY W LODZI. Poland
- Memorial Hospital of South Bend United States
- Polish Mother’s Memorial Hospital Research Institute Poland
- Uniwersytet Medyczny w Łodzi Poland
Genotype, Sequence Analysis, DNA, Middle Aged, Polymorphism, Single Nucleotide, Endometrial Neoplasms, Gene Expression Regulation, Neoplastic, Postmenopause, Alternative Splicing, Tumor Suppressor Protein p14ARF, Biomarkers, Tumor, Humans, Female, Genetic Predisposition to Disease, Alleles, Genetic Association Studies, Aged, Neoplasm Staging
Genotype, Sequence Analysis, DNA, Middle Aged, Polymorphism, Single Nucleotide, Endometrial Neoplasms, Gene Expression Regulation, Neoplastic, Postmenopause, Alternative Splicing, Tumor Suppressor Protein p14ARF, Biomarkers, Tumor, Humans, Female, Genetic Predisposition to Disease, Alleles, Genetic Association Studies, Aged, Neoplasm Staging
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).2 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!