(5′S)-8,5′-Cyclo-2′-deoxyguanosine Is a Strong Block to Replication, a Potent pol V-Dependent Mutagenic Lesion, and Is Inefficiently Repaired in Escherichia coli
Copyright policy )(5′S)-8,5′-Cyclo-2′-deoxyguanosine Is a Strong Block to Replication, a Potent pol V-Dependent Mutagenic Lesion, and Is Inefficiently Repaired in Escherichia coli
8,5'-Cyclopurines, making up an important class of ionizing radiation-induced tandem DNA damage, are repaired only by nucleotide excision repair (NER). They accumulate in NER-impaired cells, as in Cockayne syndrome group B and certain Xeroderma Pigmentosum patients. A plasmid containing (5'S)-8,5'-cyclo-2'-deoxyguanosine (S-cdG) was replicated in Escherichia coli with specific DNA polymerase knockouts. Viability was S-cdA > S-cdG. In summary, S-cdG is a major block to DNA replication, highly mutagenic, and repaired slowly in E. coli.
- University of Connecticut United States
- East Tennessee State University United States
- East Tennessee State University James H. Quillen College of Medicine United States
DNA Replication, 570, DNA Repair, Mutagenesis, Escherichia coli, 610, Deoxyguanosine, DNA-Directed RNA Polymerases, SOS Response, Genetics
DNA Replication, 570, DNA Repair, Mutagenesis, Escherichia coli, 610, Deoxyguanosine, DNA-Directed RNA Polymerases, SOS Response, Genetics
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