Nav2 is necessary for cranial nerve development and blood pressure regulation
Copyright policy )Nav2 is necessary for cranial nerve development and blood pressure regulation
Abstract Background All-trans retinoic acid (atRA) is required for nervous system development, including the developing hindbrain region. Neuron navigator 2 (Nav2) was first identified as an atRA-responsive gene in human neuroblastoma cells (retinoic acid-induced in neuroblastoma 1, Rainb1), and is required for atRA-mediated neurite outgrowth. In this paper, we explore the importance of Nav2 in nervous system development and function in vivo. Results Nav2 hypomorphic homozygous mutants show decreased survival starting at birth. Nav2 mutant embryos show an overall reduction in nerve fiber density, as well as specific defects in cranial nerves IX (glossopharyngeal) and X (vagus). Nav2 hypomorphic mutant adult mice also display a blunted baroreceptor response compared to wild-type controls. Conclusions Nav2 functions in mammalian nervous system development, and is required for normal cranial nerve development and blood pressure regulation in the adult.
- David Geffen School of Medicine at UCLA United States
- University of California, Los Angeles United States
- University of Wisconsin System United States
- University of Wisconsin–Madison United States
- University of Wisconsin–Oshkosh United States
Embryonic Development, Blood Pressure, Nerve Tissue Proteins, Pressoreceptors, Mice, Developmental Neuroscience, Research article, Animals, RC346-429, Glossopharyngeal Nerve, In Situ Hybridization, Mice, Knockout, Neurons, Homozygote, Cranial Nerves, Gene Expression Regulation, Developmental, Vagus Nerve, Immunohistochemistry, Mice, Inbred C57BL, Rhombencephalon, Mutation, Neurology. Diseases of the nervous system
Embryonic Development, Blood Pressure, Nerve Tissue Proteins, Pressoreceptors, Mice, Developmental Neuroscience, Research article, Animals, RC346-429, Glossopharyngeal Nerve, In Situ Hybridization, Mice, Knockout, Neurons, Homozygote, Cranial Nerves, Gene Expression Regulation, Developmental, Vagus Nerve, Immunohistochemistry, Mice, Inbred C57BL, Rhombencephalon, Mutation, Neurology. Diseases of the nervous system
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).47 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!