A new model of Hantaan virus persistence in mice: the balance between HTNV infection and CD8+ T-cell responses
Copyright policy )A new model of Hantaan virus persistence in mice: the balance between HTNV infection and CD8+ T-cell responses
We established a viral persistence model that involves the adoptive transfer of spleen cells from immunocompetent mice (H-2(d)) into Hantaan virus (HTNV)-infected severe combined immunodeficient (SCID, H-2(d)) mice. The infection is maintained despite the presence of neutralizing antibodies, without apparent signs of disease, and there is a correlation between HTNV persistence and the lack of HTNV-specific CD8(+) T cells. In addition, disseminated HTNV infection before the initiation of immune responses appears to be important for virus persistence. The suppression of HTNV-specific CD8(+) T cells in the present model appears to occur at the periphery. The present study also demonstrates that CD8(+) T cells contribute to the clearance of HTNV. Thus, it seems that HTNV-specific CD8(+) T cells play a key role in HTNV persistence in mice. This model of viral persistence is useful for studies of immune responses and immunocytotherapy against viral infection.
- Hokkaido University Japan
- Hokkaido Bunkyo University Japan
- Hokkeido University Japan
Cytotoxicity, Immunologic, Mice, Inbred BALB C, Viral Core Proteins, Adoptive transfer, Mice, Nude, Persistent infection, CD8-Positive T-Lymphocytes, Adoptive Transfer, Hantaan virus, Disease Models, Animal, Mice, SCID mice, Virology, Hemorrhagic Fever with Renal Syndrome, Chronic Disease, Animals, Humans, Capsid Proteins, CD8+ T cell, Hantavirus
Cytotoxicity, Immunologic, Mice, Inbred BALB C, Viral Core Proteins, Adoptive transfer, Mice, Nude, Persistent infection, CD8-Positive T-Lymphocytes, Adoptive Transfer, Hantaan virus, Disease Models, Animal, Mice, SCID mice, Virology, Hemorrhagic Fever with Renal Syndrome, Chronic Disease, Animals, Humans, Capsid Proteins, CD8+ T cell, Hantavirus
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