Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds
Copyright policy )Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently poses a threat to human health. 3C-like proteinase (3CLpro) plays an important role in the viral life cycle. Hence, it is considered an attractive antiviral target protein. Whole-genome sequencing showed that the sequence homology between SARS-CoV-2 3CLpro and SARS-CoV 3CLpro is 96.08%, with high similarity in the substrate-binding region. Thus, assessing peptidomimetic inhibitors of SARS-CoV 3CLpro could accelerate the development of peptidomimetic inhibitors for SARS-CoV-2 3CLpro. Accordingly, we herein discuss progress on SARS-CoV-2 3CLpro peptidomimetic inhibitors. Inflammation plays a major role in the pathophysiological process of COVID-19. Small-molecule compounds targeting 3CLpro with both antiviral and anti-inflammatory effects are also briefly discussed in this paper.
- Zhejiang Ocean University China (People's Republic of)
- Zhejiang Chinese Medical University China (People's Republic of)
- Zhejiang Center for Disease Control and Prevention China (People's Republic of)
Drug Design, Development and Therapy, SARS-CoV-2, Anti-Inflammatory Agents, Humans, Protease Inhibitors, Review, Peptidomimetics, Antiviral Agents, Coronavirus 3C Proteases, COVID-19 Drug Treatment
Drug Design, Development and Therapy, SARS-CoV-2, Anti-Inflammatory Agents, Humans, Protease Inhibitors, Review, Peptidomimetics, Antiviral Agents, Coronavirus 3C Proteases, COVID-19 Drug Treatment
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