Aim: The purpose of the study was to evaluate the efficiency of using the osmotic laxative polyethyleneglycol 4000 (PEG) for treatment of constipation in children. Patients and methods: Under the medical practice, the 30-days course of osmotic laxative polyethyleneglycol 4000 (PEG) administration in compliance with instruction for use was scheduled for 31 children within the age group from 5 to 17 years (average age 10.0 ± 3.5 years) in order to treat the constipation. The progress of clinical presentation and electric activity indices in different regions of gastrointestinal tract was evaluated by method of Peripheral Electrogastroenterography (PEGEG). Results: Before the start of the study most children had reported the stool retention (90%), straining efforts (87%), constrained defecation (81%) and hard stool (77%). About 50% of children had reported the long time spent in the toilet (68%) and scybalous stool (55%). As a result of the treatment the stool frequency has normalized and other constipation presentations have significantly reduced in all patient. Large bowel eclectic activity indices indicated the continuous impairment of its content evacuation. Simultaneously, the progress evaluation of electric activity progress in different regions of gastrointestinal tract (Pi/PS) and the large bowel rhythmicity ratio (Kritm) indicated the improvement on its peristalsis contractility. The adverse undesired effects of medication intake were registered in no patients. Conclusion: PEG4000 is efficient and safe remedy for treatment of constipation inn children.