Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor
Copyright policy )Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor
Drosophila sequences at chromosomal positions 25D (Brk25D) and 43E (Brk43E) are similar to the TGF beta type I receptor serine/threonine kinases and are expressed broadly during embryogenesis. Brk25D binds dpp protein and bone morphogenetic protein 2 with high affinity. Mutations affecting Brk25D map to the gene thick veins and block the expression of two decapentaplegic-responsive (dpp-responsive) genes, dpp and labial, in the embryonic midgut. Defects in Brk25D receptor function combined with reduced expression of dpp ligand produce mutant phenotypes in the embryo and adult. Brk43E is the product of the gene saxophone, which also interacts with dpp. We conclude that dpp signaling in vivo is mediated by at least two receptors, Brk25D and Brk43E.
- The University of Texas at San Antonio United States
- University of Wisconsin System United States
- UW Carbone Cancer Center United States
- Memorial Sloan Kettering Cancer Center United States
- University Research Co (United States) United States
DNA, Complementary, Base Sequence, Molecular Sequence Data, Proteins, Genes, Insect, Receptors, Cell Surface, Sequence Analysis, DNA, Protein Serine-Threonine Kinases, Gene Expression Regulation, Insect Hormones, Bone Morphogenetic Proteins, Mutation, Animals, Drosophila Proteins, Drosophila, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Receptors, Transforming Growth Factor beta, Sequence Alignment
DNA, Complementary, Base Sequence, Molecular Sequence Data, Proteins, Genes, Insect, Receptors, Cell Surface, Sequence Analysis, DNA, Protein Serine-Threonine Kinases, Gene Expression Regulation, Insect Hormones, Bone Morphogenetic Proteins, Mutation, Animals, Drosophila Proteins, Drosophila, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Receptors, Transforming Growth Factor beta, Sequence Alignment
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