Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome
Copyright policy )Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome
Key PointsSialic acids are critical for factor H–mediated complement regulation on endothelial cells, erythrocytes, and platelets. Impaired ability of factor H mutants to simultaneously bind sialic acid and C3b on cells explains their association with aHUS.
- University of Helsinki Finland
- Helsinki University Hospital Finland
Blood Platelets, Binding Sites, Mutation, Missense, Endothelial Cells, Complement Membrane Attack Complex, N-Acetylneuraminic Acid, Recombinant Proteins, Amino Acid Substitution, Complement Factor H, Complement C3b, Humans, Atypical Hemolytic Uremic Syndrome
Blood Platelets, Binding Sites, Mutation, Missense, Endothelial Cells, Complement Membrane Attack Complex, N-Acetylneuraminic Acid, Recombinant Proteins, Amino Acid Substitution, Complement Factor H, Complement C3b, Humans, Atypical Hemolytic Uremic Syndrome
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