Solasodine glycosides. In vitro preferential cytotoxicity for human cancer cells
Copyright policy )Solasodine glycosides. In vitro preferential cytotoxicity for human cancer cells
Solamargine [(22R,25R)-spiro-5-en-3 beta-yl-alpha-L-rhamnopyranosyl- (1----2glu)-O-alpha-L-rhamnopyranozyl (1----4glu)-beta-D-glucopyranoze], a glycoside of solasodine preferentially inhibits the uptake of tritiated thymidine by cancer cells. In contrast, solamargine at equivalent concentration, and the mono- and diglycosides of solasodine have a limited effect on the uptake of tritiated thymidine for other cell types, including unstimulated lymphocytes and lymphocytes stimulated with Con A. In contrast the solasodine glycosides do not inhibit the uptake of tritiated thymidine by lymphocytes stimulated with PHA or PWM. The inhibition of tritiated thymidine uptake by solamargine and the mono- and di-glycosides of solasodine are dependent upon their cellular uptake by endogenous endocytic lectins (EELs). The mode of action of the solasodine glycosides, in particular solamargine, appears to be the induction of cell lysis, as determined by morphological examination.
- University of Queensland Australia
- University of Queensland Australia
- University of Queensland Australia
- Royal Brisbane and Women's Hospital Australia
Cell Survival, human cancer cells, Molecular Sequence Data, Carbohydrates, Lymphocyte Activation, Tritium, Solanaceous Alkaloids, Lethal Dose 50, cytotoxic, BEC, Lectins, Tumor Cells, Cultured, Humans, 1306 Cancer Research, Glycosides, Lymphocytes, Ovarian Neoplasms, Dose-Response Relationship, Drug, in vitro, Fibroblasts, Carbohydrate Sequence, endogenous lectins, 2730 Oncology, Female, solasodine glycosides, HeLa Cells, Thymidine
Cell Survival, human cancer cells, Molecular Sequence Data, Carbohydrates, Lymphocyte Activation, Tritium, Solanaceous Alkaloids, Lethal Dose 50, cytotoxic, BEC, Lectins, Tumor Cells, Cultured, Humans, 1306 Cancer Research, Glycosides, Lymphocytes, Ovarian Neoplasms, Dose-Response Relationship, Drug, in vitro, Fibroblasts, Carbohydrate Sequence, endogenous lectins, 2730 Oncology, Female, solasodine glycosides, HeLa Cells, Thymidine
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