The loss of Drosophila APG4/AUT2 function modifies the phenotypes of cut and Notch signaling pathway mutants
Copyright policy )The loss of Drosophila APG4/AUT2 function modifies the phenotypes of cut and Notch signaling pathway mutants
A P-element line ( P0997) of Drosophila melanogaster in which the P element disrupts the Drosophila homolog of the Saccharomyces cerevisiae gene APG4/AUT2 was identified during the course of screening for cut ( ct) modifiers. The yeast gene APG4/AUT2 encodes a cysteine endoprotease directed against Apg8/Aut7 and is necessary for autophagy. The P0997 mutation enhances the wing margin loss associated with ct mutations, and also modifies the wing and eye phenotypes of Notch (N), Serrate (Ser), Delta (Dl), Hairless (H), deltex (dx), vestigial (vg) and strawberry notch (sno) mutants. These results therefore suggest an unexpected link between autophagy and the Notch signaling pathway.
Saccharomyces cerevisiae Proteins, Receptors, Notch, Sequence Homology, Amino Acid, Genetic Complementation Test, Molecular Sequence Data, Autophagy-Related Proteins, Membrane Proteins, Nuclear Proteins, Genes, Insect, Saccharomyces cerevisiae, Repressor Proteins, Cysteine Endopeptidases, Mutagenesis, Insertional, Phenotype, Mutation, Animals, Drosophila Proteins, Drosophila, Amino Acid Sequence, Microtubule-Associated Proteins
Saccharomyces cerevisiae Proteins, Receptors, Notch, Sequence Homology, Amino Acid, Genetic Complementation Test, Molecular Sequence Data, Autophagy-Related Proteins, Membrane Proteins, Nuclear Proteins, Genes, Insect, Saccharomyces cerevisiae, Repressor Proteins, Cysteine Endopeptidases, Mutagenesis, Insertional, Phenotype, Mutation, Animals, Drosophila Proteins, Drosophila, Amino Acid Sequence, Microtubule-Associated Proteins
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