A discrepancy between serological and molecular typing results led to identification of a novel HLA‐B*57 allele: HLA‐B*5728N
Copyright policy )A discrepancy between serological and molecular typing results led to identification of a novel HLA‐B*57 allele: HLA‐B*5728N
SummaryHere, we describe the characterisation of a new allelic variant of HLA‐B*57. The novel allele, HLA‐B*5728N, was identified with sequence‐based typing in a Caucasoid family. HLA‐B*5728N, differs from HLA‐B*5701 because of a nucleotide substitution at position 420 (C‐>G) resulting in a coding change from Tyrosine to a stop codon.
Male, Base Sequence, Histocompatibility Testing, Immunoblotting, Molecular Sequence Data, Genes, MHC Class I, Exons, Sequence Analysis, DNA, Polymerase Chain Reaction, White People, Amino Acid Substitution, Haplotypes, HLA-B Antigens, Sequence Homology, Nucleic Acid, Codon, Terminator, Humans, Female, Serologic Tests, Sequence Alignment, Alleles
Male, Base Sequence, Histocompatibility Testing, Immunoblotting, Molecular Sequence Data, Genes, MHC Class I, Exons, Sequence Analysis, DNA, Polymerase Chain Reaction, White People, Amino Acid Substitution, Haplotypes, HLA-B Antigens, Sequence Homology, Nucleic Acid, Codon, Terminator, Humans, Female, Serologic Tests, Sequence Alignment, Alleles
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