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PDK1 regulates platelet activation and arterial thrombosis

descriptionPublicationkeyboard_double_arrow_right Article 02 May 2013 English Publisher:American Society of HematologyJournal:Blood, volume 121, pages 3,718-3,726 (issn: 0006-4971, eissn: 1528-0020,

Authors: Xue Chen; Zhongzhou Yang; Yanhua Wang; Junling Liu; Yue Zhang; Lin Zhang; Yi Wu; +3 Authors

doi: 10.1182/blood-2012-10-461897

pmid: 23444402

PDK1 regulates platelet activation and arterial thrombosis

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Abstract

Key Points PDK1 is involved in thrombin-induced platelet activation and αIIbβ3-mediated outside-in signaling by regulating the downstream effector Gsk3β.

Related Organizations

Fudan University
China (People's Republic of)
Shanghai Jiao Tong University
China (People's Republic of)
Nanjing University
China (People's Republic of)
Nanjing University
China (People's Republic of)
Huashan Hospital
China (People's Republic of)

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Keywords

Blood Platelets, Mice, Knockout, Clot Retraction, Thrombin, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Thrombosis, Arteries, Protein Serine-Threonine Kinases, Platelet Activation, Adenosine Diphosphate, Mice, Inbred C57BL, Mice, 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid, Animals, Vasoconstrictor Agents

13 Research products, page 1 of 2

3-phosphoinositide-dependent protein kinase 1
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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	80
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%