MicroRNA-370 suppresses proliferation and promotes endometrioid ovarian cancer chemosensitivity to cDDP by negatively regulating ENG
Copyright policy )MicroRNA-370 suppresses proliferation and promotes endometrioid ovarian cancer chemosensitivity to cDDP by negatively regulating ENG
MicroRNAs (miRNAs) are a class of non-coding RNAs that post-transcriptionally inhibit gene expression. In this study, we discovered that microRNA-370 (miR-370) was down-regulated in endometrioid ovarian cancer cells. In IGROV1 and TOV112D endometrioid ovarian cancer cells, miR-370 suppressed cellular viability and colony formation. miR-370 also enhanced endometrioid ovarian cancer cell chemosensitivity to cDDP. Endoglin (ENG) was directly and negatively regulated by miR-370. In addition, hypermethylation was a potential mechanism of miR-370 epigenetic silencing. We conclude that miR-370 acts as a tumor suppressor in endometrioid ovarian cancer via ENG regulation.
- Soochow University China (People's Republic of)
- First Affiliated Hospital of Soochow University China (People's Republic of)
Ovarian Neoplasms, Base Sequence, Endoglin, Down-Regulation, Mice, Nude, Antineoplastic Agents, Receptors, Cell Surface, Gene Expression Regulation, Neoplastic, Mice, MicroRNAs, Antigens, CD, Drug Resistance, Neoplasm, Cell Line, Tumor, Animals, Humans, Female, RNA Interference, Cisplatin, Carcinoma, Endometrioid, Cell Proliferation
Ovarian Neoplasms, Base Sequence, Endoglin, Down-Regulation, Mice, Nude, Antineoplastic Agents, Receptors, Cell Surface, Gene Expression Regulation, Neoplastic, Mice, MicroRNAs, Antigens, CD, Drug Resistance, Neoplasm, Cell Line, Tumor, Animals, Humans, Female, RNA Interference, Cisplatin, Carcinoma, Endometrioid, Cell Proliferation
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