Mask Proteins Are Cofactors of Yorkie/YAP in the Hippo Pathway
Copyright policy )Mask Proteins Are Cofactors of Yorkie/YAP in the Hippo Pathway
The Hippo signaling pathway acts via the Yorkie (Yki)/Yes-associated protein (YAP) transcriptional coactivator family to control tissue growth in both Drosophila and mammals [1-3]. Yki/YAP drives tissue growth by activating target gene transcription, but how it does so remains unclear. Here we identify Mask as a novel cofactor for Yki/YAP. We show that Drosophila Mask forms a complex with Yki and its binding partner, Scalloped (Sd), on target-gene promoters and is essential for Yki to drive transcription of target genes and tissue growth. Furthermore, the stability and subcellular localization of both Mask and Yki is coregulated in response to various stimuli. Finally, Mask proteins are functionally conserved between Drosophila and humans and are coexpressed with YAP in a wide variety of human stem/progenitor cells and tumors.
- Cancer Research UK United Kingdom
- London Research Institute United Kingdom
Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Intracellular Signaling Peptides and Proteins, Nuclear Proteins, RNA-Binding Proteins, YAP-Signaling Proteins, Protein Serine-Threonine Kinases, Phosphoproteins, DNA-Binding Proteins, HEK293 Cells, Gene Expression Regulation, Trans-Activators, Animals, Drosophila Proteins, Humans, Drosophila, RNA Interference, Caco-2 Cells, Adaptor Proteins, Signal Transducing, Signal Transduction, Transcription Factors
Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Intracellular Signaling Peptides and Proteins, Nuclear Proteins, RNA-Binding Proteins, YAP-Signaling Proteins, Protein Serine-Threonine Kinases, Phosphoproteins, DNA-Binding Proteins, HEK293 Cells, Gene Expression Regulation, Trans-Activators, Animals, Drosophila Proteins, Humans, Drosophila, RNA Interference, Caco-2 Cells, Adaptor Proteins, Signal Transducing, Signal Transduction, Transcription Factors
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