Abstract Large-scale quantum computers will inevitably need quantum error correction to protect information against decoherence. Traditional error correction typically requires many qubits, along with high-efficiency error syndrome measurement and real-time feedback. Autonomous quantum error correction (AQEC) instead uses steady-state bath engineering to perform the correction in a hardware-efficient manner. We develop and realize an AQEC scheme with transmons, that actively corrects single-photon loss and passively suppresses low-frequency dephasing. Compared to uncorrected encoding, factors of 2.0, 5.1, and 1.4 improvements are experimentally witnessed for the logical zero, one, and superposition states. Our results show the potential of implementing hardware-efficient AQEC to enhance the reliability of a transmon-based quantum information processor.