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The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2004 English Publisher:Elsevier BVJournal:Developmental Biology, volume 266, pages 238-251 (issn: 0012-1606,

Copyright policy )Funded by:NIH | CHOLINERGIC REGULATION OF..., NIH | MECHANISMS OF ACTION OF C..., NIH | PHYSIOLOGICAL ROLE OF A N...

Authors: Yamaguchi, Hideki; Zhou, Cheng; Lin, Song-Chang; Durand, Beatrice; Tsai, Sophia; Tsai, Ming-Jer;

doi: 10.1016/j.ydbio.2003.10.038

pmid: 14738874

The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes

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Abstract

We report here that a member of the nuclear hormone receptor superfamily, chicken ovalbumin upstream promoter-transcription factor 1 (COUP-TFI), plays a critical role in glial cell development and subsequent central nervous system myelination. We demonstrate that COUP-TF1 is expressed in cells of oligodendrocyte lineage. Furthermore, we demonstrate that COUP-TFI null mutant mice exhibit delayed axon myelination and increased dysmyelination in the central nervous system. Using in vitro differentiation assays, we show that these myelination defects are due to delays in oligodendrocyte differentiation. Finally, in situ hybridization and transfection analysis suggests that COUP-TFI acts as an upstream regulator of SCIP/Oct-6/Tst-1, a transcription factor involved in axon myelination. Taken together, these results suggest that COUP-TFI is an important regulator of oligodendrocyte differentiation.

Related Organizations

Baylor College of Medicine
United States
BAYLOR COLLEGE OF MEDICINE
Baylor University
United States

Keywords

orphan receptor, Optic nerve, Down-Regulation, Nerve Fibers, Myelinated, optic nerve, Mice, Genes, Reporter, Animals, nuclear receptor, Promoter Regions, Genetic, Molecular Biology, In Situ Hybridization, Myelin Sheath, COUP-TFII, Mice, Knockout, COUP, COUP Transcription Factor I, [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, Brain, Cell Differentiation, Optic Nerve, Cell Biology, differentiation, Oligodendrocyte, Sciatic Nerve, COUP-TFI, [SDV.BDD.MOR] Life Sciences [q-bio]/Development Biology/Morphogenesis, Orphan receptor, DNA-Binding Proteins, Oligodendroglia, Tst-1, Nuclear receptor, Differentiation, Oct-6, Axon myelination, SCIP, Octamer Transcription Factor-6, OPC, Chickens, oligodendrocyte, Developmental Biology, Transcription Factors

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