Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
Copyright policy )Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
Interleukin 1 beta (IL-1 beta) is a potent proinflammatory factor during viral infection. Its production is tightly controlled by transcription of Il1b dependent on the transcription factor NF-kappaB and subsequent processing of pro-IL-1 beta by an inflammasome. However, the sensors and mechanisms that facilitate RNA virus-induced production of IL-1 beta are not well defined. Here we report a dual role for the RNA helicase RIG-I in RNA virus-induced proinflammatory responses. Whereas RIG-I-mediated activation of NF-kappaB required the signaling adaptor MAVS and a complex of the adaptors CARD9 and Bcl-10, RIG-I also bound to the adaptor ASC to trigger caspase-1-dependent inflammasome activation by a mechanism independent of MAVS, CARD9 and the Nod-like receptor protein NLRP3. Our results identify the CARD9-Bcl-10 module as an essential component of the RIG-I-dependent proinflammatory response and establish RIG-I as a sensor able to activate the inflammasome in response to certain RNA viruses.
- Technical University of Munich Germany
- University of Lausanne Switzerland
- Osaka University Japan
- Ludwig-Maximilians-Universität München Germany
- Saitama Medical University Japan
Inflammation, Mice, Knockout, Interferon-Induced Helicase, IFIH1, Caspase 1, Immunoblotting, Interleukin-1beta, Enzyme-Linked Immunosorbent Assay, Models, Biological, Cell Line, CARD Signaling Adaptor Proteins, DEAD-box RNA Helicases, Enzyme Activation, Mice, Host-Pathogen Interactions, Animals, DEAD Box Protein 58, Humans, Encephalomyocarditis virus, Cells, Cultured, Adaptor Proteins, Signal Transducing
Inflammation, Mice, Knockout, Interferon-Induced Helicase, IFIH1, Caspase 1, Immunoblotting, Interleukin-1beta, Enzyme-Linked Immunosorbent Assay, Models, Biological, Cell Line, CARD Signaling Adaptor Proteins, DEAD-box RNA Helicases, Enzyme Activation, Mice, Host-Pathogen Interactions, Animals, DEAD Box Protein 58, Humans, Encephalomyocarditis virus, Cells, Cultured, Adaptor Proteins, Signal Transducing
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