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Science Signaling
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Science Signaling
Article . 2012 . Peer-reviewed
Data sources: Crossref
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Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis

Authors: Chintan K, Kikani; Erik V, Verona; Jiyoon, Ryu; Yanying, Shen; Qingqing, Ye; Li, Zheng; Ziliang, Qian; +8 Authors

Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis

Abstract

PDK1 in the nucleus drives oncogenesis in mice and correlates with human prostate tumor grade.

Keywords

Cell Nucleus, Male, Mice, Knockout, Cell Survival, Active Transport, Cell Nucleus, Prostatic Neoplasms, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Apoptosis, Protein Serine-Threonine Kinases, Mice, Phosphatidylinositol 3-Kinases, Phosphoglycerate Kinase, Cell Transformation, Neoplastic, Animals, Humans, Proto-Oncogene Proteins c-akt, Cell Proliferation, Protein Binding

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    27
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
27
Top 10%
Average
Top 10%
bronze