In 2021 the sanatorium "Annenskie Vody" will be 155 years old. This is the oldest balneological institution in the Khabarovsk Territory, a Far Eastern health resort that helps restore health to the population using natural factors. Annenskie Vody sanatorium receives more than three thousand patients annually, and almost 7 % of the patients are patients with skin diseases. The main healing factor in the Annenskie Vody sanatorium is mineral water. The spring water is thermal (t 52 ºC), slightly mineralized (0.2–0.3 g/l), hydrocarbonate-sulphate-sodium, alkaline, with a high content of silicic acid. There were 560 psoriasis patients aged from 18 to 70 years under observation. Of these, 360 are women and 200 are men. To assess the severity and effectiveness of the therapy in patients with psoriasis, the PASI index was used, which decreased by 4 times during therapy. Biochemical parameters improved under the influence of AKTW. The effectiveness of therapy increased with the use of complex methods of exposure (mud therapy, physiotherapy).